Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases / 소아과
Korean Journal of Pediatrics
;
: 193-203, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-125112
ABSTRACT
PURPOSE:
To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated.METHODS:
Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3+/-4.6 months. Pharmacokinetic studies of CsA were done twice at beginning and closing of 12 months' CsA therapy.RESULTS:
The steady state CsA pharmacokinetic parameters of 34 patients were as follows; Tmax1.64+/-0.84 hr, Cmax788+/-354 ng/dL, C1258.7+/-33.2 ng/mL, Cavg246+/-96 ng/mL, AUC2,949+/-1,156 ng hr/mL, Vd4.03+/-0.45 L/kg, CL9.69+/-2.27 L/hr, T1/25.31+/-2.37 hr. C2 was the best to predict the CsA AUC(R=0.896, P<0.001). Body surface area based dosage(mg/m2/d) correlates best with AUC. Intra-individual CsA pharmacokinetic changes were not found after 12 months' therapy. Anti-proteinuric effect of CsA was considerable; 88.9% of primary nephrotic syndrome and 62.5% of secondary glomerular diseases was responsive to CsA thearpy. There was no serious complication and CsA treatment was well tolerated by the pediatric patients.CONCLUSION:
CsA therapy for difficult renal diseases with proteinuria was effective and safe. For better AUC prediction of CsA, body surface area based dosage(mg/m2/d) and C2 monitoring are recommended in children with renal diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteinuria
/
Superficie Corporal
/
Farmacocinética
/
Ciclosporina
/
Área Bajo la Curva
/
Síndrome Nefrótico
Tipo de estudio:
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2004
Tipo del documento:
Artículo
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