The Prevalence of Transfusion-Transmitted Virus Infection in Children / 소아과
Korean Journal of Pediatrics
; : 183-186, 2004.
Article
en Ko
| WPRIM
| ID: wpr-125114
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Transfusion-transmitted virus(TTV) is an newly described nonenveloped human virus, with a circular, negative stranded DNA genome. Although a high prevalence of TTV infection in the normal population has been demonstrated, there is a still possibility of association with hepatitis according to the genotype of TTV. The aim of this study is to investigate the prevalence of TTV infection in Korean children. METHODS: Nested polymerase chain reaction(PCR) using priner sets generated from the noncoding region(NCR) of the viral genome was done in 105 children without liver disease, aged 0-15 years. We performed a second set of PCR using N22 primer in 88 children after the first set of PCR. RESULTS: The TTV DNA was detectable in 36(34%) of 105 children without hepatitis by 5'NCR primer. The prevalence of TTV varied with age:<1 y,16%(4/25); 1-3 y, 44%(15/31); 4-6 y, 31%(5/ 16); 7-9 y, 25%(3/12); 10-15 y, 14%(3/21). By using N22 primers, the prevalence of TTV DNA in children without hepatitis was 11.3%(11/88):<1 y 8%(2/25); 1-3 y, 13.7%(4/29); 4-6 y, 6.2%(1/16); 7-9 y, 33.3%(2/6); 10-14 y, 8.2%(1/12). CONCLUSION: Our result showed a high prevalence of TTV infection, varying with age, in Korean children. Further evaluation of genotypes of TTV in patients with hepatitis and normal children is needed.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
ADN
/
Reacción en Cadena de la Polimerasa
/
Prevalencia
/
Genoma Viral
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Genoma
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Torque teno virus
/
Genotipo
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Hepatitis
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Hepatopatías
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Pediatrics
Año:
2004
Tipo del documento:
Article