Usage of T Cell receptor repertoire is restricted in synovial lymphocytes in rheumatoid arthritis
Immune Network
;
: 70-76, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-125535
ABSTRACT
BACKGROUND:
Rheumatoid arthritis is an autoimmune disease characterized by a chronic inflammatory process, primarily involving the synovial membrane of peripheral joints, where T cell activation is found. To address the superantigen stimulation in rheumatoid arthritis, T cell clonality and the expression of activation markers were analyzed.METHODS:
To detect TCRB V usage, inverse PCR and sequencing were done. Monoclonal antibodies were used for flow cytometric analysis of TCRBV8 or TCRBV5. As result s, a restricted usage of TCRBV3 gene was detected in synovial lymphocytes from one rheumatoid arthritis patient . However, preferential usage for TCRB V8, which may be one indicator for stimulation by staphylococcal superantigen, was not obvious although general activation of T cells was found as high DR+ percentage in synovial T cells. These data show specific antigen rather than superantigen might involve the pathogenesis of rheumatoid arthritis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Artritis Reumatoide
/
Enfermedades Autoinmunes
/
Membrana Sinovial
/
Linfocitos
/
Receptores de Antígenos de Linfocitos T
/
Linfocitos T
/
Reacción en Cadena de la Polimerasa
/
Articulaciones
/
Anticuerpos Monoclonales
Límite:
Humanos
Idioma:
Coreano
Revista:
Immune Network
Año:
2001
Tipo del documento:
Artículo
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