Evaluation of Quantitative culture of Clostridium difficile From Fecal Specimens for the Diagnosis of C. difficile-associated Disease / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
;
: 124-128, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-125720
ABSTRACT
BACKGROUND:
C. difficile-associated diarrhea (CDAD), the most frequently identified cause of nosocomial diarrhea, results from the overgrowth of cytotoxin (toxin B)-producing strains. The aim of this study was to evaluate the quantitative culture of Clostridium difficile to improve the laboratory diagnosis of CDAD.METHODS:
The quantitative culture and cytotoxin gene results were evaluated based on the findings of colonoscopy and/or histology of the biopsy specimens.RESULTS:
Among the 402 specimens with cytotoxin-positive isolates, 301 (74.9%) contained > or =106 CFU/mL of C. difficile. Nine (60%) of the 15 pseudomembranous colitis patients yielded > or =106 CFU/mL of toxigenic isolate. The proportion of cytotoxin gene-positive isolates was higher in the specimens with > or =106 CFU/mL of C. difficile than in those with 102-<103 CFU/mL (86.5% vs. 66.7%).CONCLUSIONS:
Quantitative culture may aid in the interpretation of toxigenic C. difficile culture results, and reduce false positivity, thus avoiding unnecessary treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biopsia
/
Enterocolitis Seudomembranosa
/
Clostridioides difficile
/
Colonoscopía
/
Clostridium
/
Técnicas de Laboratorio Clínico
/
Diagnóstico
/
Diarrea
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Microbiology
Año:
2002
Tipo del documento:
Artículo
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