Is additional acid-suppressing agents needed after the initial Helicobacter pylori eradication therapy to heal peptic ulcers? / 대한내과학회지
Korean Journal of Medicine
;
: 439-443, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-12574
ABSTRACT
BACKGROUND:
Helicobacter pylori (H. pylori) can now be eradicated in the majority of patients with 7 days of treatment with OAC (omeprazole+amoxicillin+clarithromycin) regimen. It is unclear if additional acid-suppressing treatment should be continued beyond 7 days in patients with active gastric or duodenal ulcers.METHODS:
Ninety two patients with endoscopically proven active peptic ulcers who were H. pylori positive were randomized to receive either omeprazole 20 mg plus amoxicillin 1.0g plus clarithromycin 500mg ; twice daily for 1 week alone (OAC group) or same regimen followed by 3 weeks of omeprazole (OACP group). Endoscopy and UBT (urea breath test) were performed 8 weeks after the initiation of treatment.RESULTS:
Forty four of forty five (97.8%) of OAC group and forty four of forty seven (93.6%) of OACP group were noted to have healed ulcer at week 8.CONCLUSION:
In patients with H. pylori infection and peptic ulcers, one week of OAC therapy without further need for PPI may heal the ulcers. Following an l week course of H. pylori eradication therapy by OAC for peptic ulcers, further 3 weeks of acid-suppressing therapy with PPI was not proven to promote ulcer healing rate.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Úlcera Péptica
/
Úlcera
/
Omeprazol
/
Helicobacter pylori
/
Helicobacter
/
Claritromicina
/
Úlcera Duodenal
/
Endoscopía
/
Amoxicilina
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2001
Tipo del documento:
Artículo
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