Clinical characteristics of acute Q fever in Daegu area / 대한내과학회지
Korean Journal of Medicine
; : 404-411, 2010.
Article
en Ko
| WPRIM
| ID: wpr-125932
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: Although only a few sporadic cases of Q fever have been reported in Korea, a total of 13 cases have been seen in our area. We performed this study to evaluate the clinical characteristics of these cases of acute Q fever. METHODS: Demographic features, clinical manifestations, laboratory and radiologic findings, and therapeutic outcomes of all cases were evaluated. Q fever was diagnosed using an indirect micro-immunofluorescence assay (MIFA) and polymerase chain reaction (PCR). RESULTS: A total of 13 patients with acute Q fever seen from January 2006 to August 2008 at three teaching hospitals in the Daegu Metropolitan City area were enrolled. The mean age was 49 years old (range, 24~76), and the male to female ratio was 11:2. Six (46.2%) cases had a history of animal contact. Fever (100%) was the most common manifestation, followed by myalgia (84.6%), headache (61.5%), anorexia (61.5%), and chills (61.5%). All cases were diagnosed with high titers of anti-phase II antibody (IgM> or = 1:50, IgG> or =1:200) and positive nested PCR for the 27-kDa OMP com-1 gene of Coxiella burnettii in the blood. In three cases, liver biopsies revealed the presence of compact fibrin-ring granulomas. No characteristics of pneumonia were diagnosed on chest X-rays. The predominant presentation was acute febrile illness with hepatitis, including three cases (27.3%) of severe cholestatic hepatitis. The most frequently used antimicrobial agent was doxycycline (84.6%), followed by azithromycin (7.7%). CONCLUSIONS: Acute Q fever may be added to the list of differential diagnosis of patients with acute febrile illness and hepatitis in the Daegu Metropolitan City area.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Neumonía
/
Fiebre Q
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Tórax
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Biopsia
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Anorexia
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Reacción en Cadena de la Polimerasa
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Doxiciclina
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Azitromicina
/
Coxiella
/
Escalofríos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
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Female
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Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Medicine
Año:
2010
Tipo del documento:
Article