Efficacy of Oxidized Regenerated Cellulose, SurgiGuard®, in Porcine Surgery
Yonsei Medical Journal
;
: 195-205, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-126256
ABSTRACT
PURPOSE:
Adequate hemostasis is important for postoperative outcomes of abdominal surgery. This study evaluated the hemostatic effects and accompanying histopathological changes of a novel oxidized regenerated cellulose, SurgiGuard®, during abdominal surgery. MATERIALS ANDMETHODS:
Ten pigs underwent wedge resection of the spleen (1×1 cm) and liver (1.5×1.5 cm). The resected surface was covered with Surgicel® fabric or fibril type (Group A) or SurgiGuard® fabric or fibril type (Group B). Surgicel® and SurgiGuard® were randomized for attachment to the resected surface by fabric type (n=5) or fibril type (n=5). Blood loss was measured 5, 7, and 9 min after resection. Pigs were necropsied 6 weeks postoperatively to evaluate gross and histopathological changes.RESULTS:
There was no significant difference in total blood loss between groups [spleen fabric Group A vs. Group B, 4.38 g (2.74–6.43) vs. 3.41 g (2.46–4.65), p=0.436; spleen fibril Group A vs. Group B, 3.44 g (2.82–6.07) vs. 3.60 g (2.03–6.09), p=0.971; liver fabric Group A vs. Group B, 4.51 g (2.67–10.61) vs. 6.93 g (3.09–9.95), p=0.796; liver fibril Group A vs. Group B, 3.32 g (2.50–8.78) vs. 3.70 g (2.32–5.84), p=0.971]. Histopathological analysis revealed no significant difference in toxicities related to Surgicel® or SurgiGuard® [inflammation, fibrosis, foreign bodies, and hemorrhage (spleen p=0.333, 0.127, 0.751, and 1.000; liver p=0.155, 0.751, 1.000, and 1.000, respectively)].CONCLUSION:
SurgiGuard® is as effective and non-toxic as Surgicel® in achieving hemostasis after porcine abdominal surgery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bazo
/
Porcinos
/
Hemostáticos
/
Distribución Aleatoria
/
Celulosa Oxidada
/
Pérdida de Sangre Quirúrgica
/
Hemostasis Quirúrgica
/
Hígado
Límite:
Animales
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2017
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS