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A Case of Primary Gastric ALK-Positive Anaplastic Large-Cell Lymphoma / 대한내과학회지
Korean Journal of Medicine ; : 752-756, 2012.
Artículo en Coreano | WPRIM | ID: wpr-126602
ABSTRACT
Anaplastic large-cell lymphoma (ALCL) is a rare subgroup of non-Hodgkin's lymphoma. Primary gastric ALCL is extremely rare. Patients with anaplastic lymphoma kinase (ALK)-positive primary systemic ALCL are known to have better overall survival than those with ALK-negative ALCL. We herein report a case of primary gastric ALK-positive anaplastic large-cell lymphoma. A 37-year-old woman presented with postprandial epigastric pain for 2 months. Endoscopic examination of the upper gastrointestinal tract showed multiple variably sized, round, elevated lesions with friable crater-erosion on the body and fundus. Pathologic examination revealed atypical large lymphoid cell infiltration in the lamina propria; the cells were positive for CD3, CD30, and ALK. We diagnosed the patient with ALCL. She underwent a cycle of chemotherapy with cyclophosphamide, adriamycin, vincristine, and prednisolone. However, she developed brain metastases. Despite two cycles of palliative chemotherapy with high-dose methotrexate for brain metastases, she died due to ALCL progression.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfotransferasas / Neoplasias Gástricas / Vincristina / Linfoma no Hodgkin / Encéfalo / Prednisolona / Linfocitos / Doxorrubicina / Metotrexato / Proteínas Tirosina Quinasas Receptoras Límite: Adulto / Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfotransferasas / Neoplasias Gástricas / Vincristina / Linfoma no Hodgkin / Encéfalo / Prednisolona / Linfocitos / Doxorrubicina / Metotrexato / Proteínas Tirosina Quinasas Receptoras Límite: Adulto / Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Año: 2012 Tipo del documento: Artículo