Your browser doesn't support javascript.
loading
Clinical Characteristics and Metabolic Features of Patients with Adrenal Incidentalomas with or without Subclinical Cushing's Syndrome
Endocrinology and Metabolism ; : 457-463, 2014.
Artículo en Inglés | WPRIM | ID: wpr-126651
ABSTRACT

BACKGROUND:

The aim of this study was to examine the clinical characteristics of adrenal incidentalomas discovered by computed tomography (CT) and to investigate metabolic features of subclinical Cushing's syndrome (SCS) in patients with adrenal incidentalomas in a tertiary hospital in Korea.

METHODS:

This retrospective study examined the clinical aspects of 268 patients with adrenal incidentalomas discovered by CT at Soonchunhyang University Bucheon Hospital. Clinical data and endocrine function of the patients as well as histological findings were obtained from medical records, while anatomic characteristics were analyzed by reviewing imaging studies. Hormonal tests for pheochromocytoma, Cushing's syndrome, and aldosterone-secreting adenoma were performed.

RESULTS:

Most (n=218, 81.3%) cases were nonfunctioning tumors. Of the 50 patients with functioning tumors (18.7%), 19 (7.1%) were diagnosed with SCS, nine (3.4%) with overt Cushing's syndrome, 12 (4.5%) with primary aldosteronism, and 10 (3.7%) with pheochromocytoma. Malignant tumors (both primary and metastatic) were rare (n=2, 0.7%). Body mass index, fasting glucose, hemoglobin A1c, and total cholesterol were significantly higher in patients with SCS in comparison with those with nonfunctioning tumors. The prevalence of type 2 diabetes mellitus and hypertension were significantly higher in patients with SCS compared with those with nonfunctioning tumors.

CONCLUSION:

Functioning tumors, especially those with subclinical cortisol excess, are commonly found in patients with adrenal incidentalomas, although malignancy is rare. In addition, patients with SCS in adrenal incidentalomas have adverse metabolic and cardiovascular profiles.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Feocromocitoma / Hidrocortisona / Adenoma / Índice de Masa Corporal / Registros Médicos / Colesterol / Prevalencia / Estudios Retrospectivos / Ayuno / Síndrome de Cushing Tipo de estudio: Estudio observacional / Estudio de prevalencia Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Endocrinology and Metabolism Año: 2014 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Feocromocitoma / Hidrocortisona / Adenoma / Índice de Masa Corporal / Registros Médicos / Colesterol / Prevalencia / Estudios Retrospectivos / Ayuno / Síndrome de Cushing Tipo de estudio: Estudio observacional / Estudio de prevalencia Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Endocrinology and Metabolism Año: 2014 Tipo del documento: Artículo