Novel Methods for Clinical Risk Stratification in Patients with Colorectal Liver Metastases / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 242-250, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-126955
ABSTRACT
PURPOSE:
Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. MATERIALS ANDMETHODS:
Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA).RESULTS:
The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001).CONCLUSION:
The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Anafilaxis Cutánea Pasiva
/
Neoplasias Colorrectales
/
Antígeno Carcinoembrionario
/
Oportunidad Relativa
/
Tasa de Supervivencia
/
Análisis de Componente Principal
/
Hígado
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2015
Tipo del documento:
Artículo
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