Usefulness of specific IgE antibody levels to wheat, gluten, and ω-5 gliadin for wheat allergy in Korean children
Allergy, Asthma & Respiratory Disease
;
: 119-125, 2016.
Artículo
en Coreano
| WPRIM
| ID: wpr-127230
ABSTRACT
PURPOSE:
The aim of this study was to assess the clinical usefulness and added diagnostic value of specific IgE antibodies to wheat, gluten, and ω-5 gliadin in diagnosing wheat allergy and distinguishing wheat anaphylaxis.METHODS:
This study included 196 children who visited Ajou University Hospital for suspicious food allergy. The subjects were divided into 2 groups the wheat allergy (WA) and non-wheat allergy (non-WA) groups. Patients with wheat allergy were further divided into 2 subgroups according to their symptoms the wheat allergy with anaphylaxis (WA(Ana)) and wheat allergy without anaphylaxis (WA(Non-Ana)) groups. Serum concentrations of total IgE and specific IgE antibodies to wheat, gluten and ω-5 gliadin were measured.RESULTS:
The median values of specific IgE antibodies to wheat, gluten and ω-5 gliadin were significantly higher in the WA group than in the non-WA group, and the positive decision points (95% specificity) were at 3.12, 2.61, and 0.21 kUA/L, respectively. The combination of specific IgE antibodies to wheat and ω-5 gliadin resulted in the highest accuracy of 93.9% in diagnosing wheat allergy. In differentiating the WA(Ana) group from the WA(Non-Ana) group, only specific IgE antibody to ω-5 gliadin showed a significant difference at the optimal cutoff point of 1.56 kUA/L.CONCLUSION:
Our results show that the individual levels of specific IgE antibodies to wheat, gluten or ω-5 gliadin may have a considerably high accuracy in diagnosing wheat allergy and that specific IgE antibody to ω-5 gliadin may be particularly useful in predicting wheat anaphylaxis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Triticum
/
Inmunoglobulina E
/
Hipersensibilidad al Trigo
/
Hipersensibilidad a los Alimentos
/
Gliadina
/
Glútenes
/
Hipersensibilidad
/
Anafilaxia
/
Anticuerpos
Tipo de estudio:
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Allergy, Asthma & Respiratory Disease
Año:
2016
Tipo del documento:
Artículo
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