ABO Incompatible Living Donor Kidney Transplantation with Rituximab and Plasmapheresis: A Single Center Experience / 대한신장학회지
Korean Journal of Nephrology
;
: 386-393, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-127452
ABSTRACT
PURPOSE:
ABO incompatibility had long been an obstacle in kidney transplantation. However, recent reports showed excellent outcomes. In this study, we evaluated the outcomes of ABO incompatible kidney transplantation with preconditioning protocol using rituximab and plasmapheresis.METHODS:
The recipients who had an ABO-incompatible donor and underwent living donor kidney transplantation were enrolled. Preconditioning protocol was pretransplant single dose rituximab with plasmapheresis at pretransplantation 7-10 days. Immune suppression regimen consisted of tacrolimus, mycophenolate mofetil and steroid. Anti-A or anti-B antibody titer was monitored during preconditioning and post transplantation period.RESULTS:
37 patients underwent living donor ABO incompatible kidney transplantation. Median pre-treatment antibody titer was 164 and pre transplant antibody titer after 1-6 times of plasmapheresis was 12. Median follow-up duration was 332 days (range 156-681). One episode of acute T cell mediated rejection was observed. Mean serum creatinine at 2 weeks was 1.00+/-0.27 mg/dL and at 24 weeks was 1.21+/-0.37 mg/dL.CONCLUSION:
ABO incompatible kidney transplantation with rituximab and plasmapheresis can be safely performed. It is therefore a valuable option for expanding donor pool and should be actively performed in Korea.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Rechazo en Psicología
/
Donantes de Tejidos
/
Estudios de Seguimiento
/
Trasplante de Riñón
/
Plasmaféresis
/
Tacrolimus
/
Donadores Vivos
/
Trasplantes
/
Creatinina
/
Anticuerpos Monoclonales de Origen Murino
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Año:
2011
Tipo del documento:
Artículo
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