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A focus on extracellular Ca²⁺ entry into skeletal muscle
Experimental & Molecular Medicine ; : e378-2017.
Artículo en Inglés | WPRIM | ID: wpr-127721
ABSTRACT
The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca²⁺ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca²⁺ level is mainly determined by Ca²⁺ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca²⁺ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca²⁺ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca²⁺ entryway into skeletal muscle. Herein, recent studies on extracellular Ca²⁺ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca²⁺ entry and their influences on skeletal muscle function and disease.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Postura / Relajación / Retículo Sarcoplasmático / Cinética / Músculo Esquelético / Proteínas Contráctiles / Citosol / Espacio Extracelular Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Postura / Relajación / Retículo Sarcoplasmático / Cinética / Músculo Esquelético / Proteínas Contráctiles / Citosol / Espacio Extracelular Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2017 Tipo del documento: Artículo