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Association of T Antigens with emm Genotypes of Group A Streptococci / 대한임상미생물학회지
Korean Journal of Clinical Microbiology ; : 18-23, 2006.
Artículo en Coreano | WPRIM | ID: wpr-128147
ABSTRACT

BACKGROUND:

T typing has been used as a screening test for epidemiologic studies of group A streptococci (GAS) infections or carriers, and M typing has been performed for virulence studies. However, M typing is difficult to perform in routine laboratories. Recently, genotyping of the emm gene, which encodes the M protein, has become available. We investigated which T antigen is closely associated with a certain emmgenotype.

METHODS:

GAS were collected from the children in Jinju who were asymptomatic carriers (N=349) or had acute pharyngitis (N=122) during the 3 year-period from 2002 through 2004. T typing was performed by a slide aggulutination, and emmgenotyping by PCR and DNA sequencing.

RESULTS:

More than 90% of T1, T3, T6, T12, T25, and T5/27/44 antigens were associated with emm1, emm3, emm6, emm12 and 22, emm75, and emm44/61 genotypes, respectively; however, other T antigens, such as T2, T4, T7, T11, and B3264, were not associated with any particular emm genotypes.

CONCLUSION:

Several T antigens are so closely associated with particular emm genotypes that one could predict emmgenotypes based on the result of T typing.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Streptococcus pyogenes / Virulencia / Faringitis / Tamizaje Masivo / Reacción en Cadena de la Polimerasa / Epidemiología / Análisis de Secuencia de ADN / Genotipo / Antígenos Virales de Tumores Tipo de estudio: Estudio de tamizaje Límite: Niño / Humanos Idioma: Coreano Revista: Korean Journal of Clinical Microbiology Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Streptococcus pyogenes / Virulencia / Faringitis / Tamizaje Masivo / Reacción en Cadena de la Polimerasa / Epidemiología / Análisis de Secuencia de ADN / Genotipo / Antígenos Virales de Tumores Tipo de estudio: Estudio de tamizaje Límite: Niño / Humanos Idioma: Coreano Revista: Korean Journal of Clinical Microbiology Año: 2006 Tipo del documento: Artículo