Association of T Antigens with emm Genotypes of Group A Streptococci / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
;
: 18-23, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-128147
ABSTRACT
BACKGROUND:
T typing has been used as a screening test for epidemiologic studies of group A streptococci (GAS) infections or carriers, and M typing has been performed for virulence studies. However, M typing is difficult to perform in routine laboratories. Recently, genotyping of the emm gene, which encodes the M protein, has become available. We investigated which T antigen is closely associated with a certain emmgenotype.METHODS:
GAS were collected from the children in Jinju who were asymptomatic carriers (N=349) or had acute pharyngitis (N=122) during the 3 year-period from 2002 through 2004. T typing was performed by a slide aggulutination, and emmgenotyping by PCR and DNA sequencing.RESULTS:
More than 90% of T1, T3, T6, T12, T25, and T5/27/44 antigens were associated with emm1, emm3, emm6, emm12 and 22, emm75, and emm44/61 genotypes, respectively; however, other T antigens, such as T2, T4, T7, T11, and B3264, were not associated with any particular emm genotypes.CONCLUSION:
Several T antigens are so closely associated with particular emm genotypes that one could predict emmgenotypes based on the result of T typing.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Streptococcus pyogenes
/
Virulencia
/
Faringitis
/
Tamizaje Masivo
/
Reacción en Cadena de la Polimerasa
/
Epidemiología
/
Análisis de Secuencia de ADN
/
Genotipo
/
Antígenos Virales de Tumores
Tipo de estudio:
Estudio de tamizaje
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Microbiology
Año:
2006
Tipo del documento:
Artículo
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