Bladder Preserving Treatment in Patients with Muscle Invasive Bladder Cancer / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology
;
: 70-78, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-12822
ABSTRACT
PURPOSE:
This study analyzed the tumor response, overall survival, progression free survival and related prognostic factors in patients with muscle invasive bladder cancer subjected to bladder preserving treatment. MATERIALS ANDMETHODS:
Between August 1995 and June 2004, 37 patients with muscle invasive (transitional cell carcinoma, clinically stage T2-4) bladder cancer were enrolled for the treatment protocol of bladder preservation. There were 33 males and 4 females, and the median age was 67 years (range 38~86 years). Transurethral resection of the bladder (TURB) was performed in 17 patients who underwent complete resection. The median radiation dose administered was 64.8 Gy (range 55.8~67 Gy). The survival rate was calculated by the Kaplan-Meier method.RESULTS:
An evaluation of the response rate was determined by abdomen-pelvic CT and cystoscopy at three months after radiotherapy. A complete response was seen in 17 patients (46%). The survival rate at three years was 54.7%, with 54 months of median survival (range 3~91 months). During the study, 17 patients died and 13 patients had died from bladder cancer. The progression free survival rate at three years was 37.2%. There were 24 patients (64.9%) who had disease recurrence 16 patients (43.2%) had local recurrence, 6 patients (16.2%) had a distant recurrence, and 2 patients (5.4%) had both a local and distant recurrence. The survival rate (p=0.0009) and progression free survival rates (p=0.001) were statistically significant when compared to the response rate after radiotherapy.CONCLUSION:
The availability of complete TURB and appropriate chemoradiotherapy were important predictors for bladder preservation and survival.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Radioterapia
/
Recurrencia
/
Vejiga Urinaria
/
Neoplasias de la Vejiga Urinaria
/
Protocolos Clínicos
/
Tasa de Supervivencia
/
Supervivencia sin Enfermedad
/
Cistoscopía
/
Quimioradioterapia
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Journal of the Korean Society for Therapeutic Radiology and Oncology
Año:
2007
Tipo del documento:
Artículo
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