Cyclooxygenase-2 Expression and Angiogenesis in Invasive Cervical Cancer / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 399-403, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-128669
ABSTRACT
OBJECTIVE:
A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumor growth and angiogenesis of gastrointestinal and other cancers. This was the study to determine the relationship between tumor vascularity and COX-2 expression in invasive cervical cancer.METHODS:
We examined the expression of COX-2 and microvessel density (MVD) by immunohis- tochemical staining in 21 specimens collected from invasive cervical cancer patients.RESULTS:
All specimens showed weak and strong immunoreactivity, with 52.4% strong reactivity. Microvessel count was higher (median 136) in the strong COX-2 immunoreactivity specimens than the weaks (median 90), and MVD was significantly correlated with the COX-2 immunoreactivity (P=0.002).CONCLUSION:
These preliminary data indicate that overexpression of COX-2 may play an important role in carcinogenesis of cervical cancer and this could be partially attributable to modulation of angiogenesis by COX-2. COX-2 maybe a target for future research in the tumorigenesis of the invasive cervical cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias del Cuello Uterino
/
Ciclooxigenasa 2
/
Microvasos
/
Carcinogénesis
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2002
Tipo del documento:
Artículo
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