Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells
Diabetes & Metabolism Journal
; : 91-105, 2013.
Article
en En
| WPRIM
| ID: wpr-128753
Biblioteca responsable:
WPRO
ABSTRACT
Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Nervios Periféricos
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Células Madre
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Médula Ósea
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Enfermedades Cardiovasculares
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Úlcera del Pie
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Inductores de la Angiogénesis
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Neuropatías Diabéticas
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Extremidades
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Manejo del Dolor
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Tratamiento Basado en Trasplante de Células y Tejidos
Límite:
Adult
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Humans
Idioma:
En
Revista:
Diabetes & Metabolism Journal
Año:
2013
Tipo del documento:
Article