Diffuse alveolar hemorrhage and recombinant factor VIIa treatment in pediatric patients / 소아과
Korean Journal of Pediatrics
; : 105-113, 2016.
Article
en En
| WPRIM
| ID: wpr-128909
Biblioteca responsable:
WPRO
ABSTRACT
Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders. The current treatment options, which include corticosteroids, transfusions, extracorporeal membrane oxygenation (ECMO), and immunosuppressants, have been limited and largely unsuccessful. Recombinant activated factor VII (rFVIIa) has been successfully administered, either systemically or bronchoscopically, to adults for the treatment of DAH, but there are few data on its use in pediatric patients. The current literature in the PubMed database was reviewed to evaluate the efficacy and risk of rFVIIa treatment for DAH in pediatric patients. This review discusses the diagnosis and treatment of DAH, as well as a new treatment paradigm that includes rFVIIa. Additionally, the risks and benefits of off-label use of rFVIIa in pediatric patients are discussed.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Oxigenación por Membrana Extracorpórea
/
Factor VIIa
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Corticoesteroides
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Medición de Riesgo
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Neoplasias Hematológicas
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Diagnóstico
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Uso Fuera de lo Indicado
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Hemorragia
/
Inmunosupresores
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Año:
2016
Tipo del documento:
Article