The Infusion Rate of Mivacurium for Cesarean Section and its Spontaneous Recovery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 198-205, 1996.
Artículo
en Coreano
| WPRIM
| ID: wpr-128930
ABSTRACT
BACKGROUND:
Mivacurium is a nondepolarizing muscle relaxant and metabolized by pseudo-cholinesterase(pChe). Many reports show fall in pChe activity during pregnancy, so the metabolism of mivacurium may be delayed and muscle relaxation would be prolonged.METHODS:
Muscle relaxation of full-term pregnant women(C group, n=10) and nopregnant women(Non-C group, n=10) was maintained by continuous infusion of mivacurium to keep 1st response of TOF at 5+/-1%. After discontinuance of infusion, recovery profiles were measured with accelerography.RESULTS:
The Infusion rate of mivacurium to maintain 1st twich response of TOF at 5+/-1% was significantly low in C group comparing with Non-C group(P<0.05). There was no significant difference in pChe activity between two groups. There was no significant difference in recovery index, recovery time(T1 25%-T4 ratio, 0.75). There was a little correlation between the total infusion time and recovery profiles(recovery index r2=0.37, recovery time r2=0.28). Strong correlation existed between bolus-TS(time interval from the injection of mivacurium to recovery of 5% twitch hight) and infusion rate(r2=0.76).CONCLUSION:
The mivacurium infusion rate of C group to maintain muscle relaxation was significantly lower than Non-C group. There would be many possible reasons including over-estimation of paturient body weight compared with lean body mass, decrease of blood volume due to hemorrhage.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Volumen Sanguíneo
/
Peso Corporal
/
Butirilcolinesterasa
/
Cesárea
/
Hemorragia
/
Metabolismo
/
Relajación Muscular
/
Obstetricia
Límite:
Embarazo
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Año:
1996
Tipo del documento:
Artículo
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