Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes / 대한수의학회지
Korean Journal of Veterinary Research
;
: 189-192, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-129066
ABSTRACT
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20 microg/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4x MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas Medicinales
/
Streptococcus
/
Streptococcus pyogenes
/
Pruebas de Sensibilidad Microbiana
/
Tasa de Supervivencia
/
Resultado del Tratamiento
/
Glycyrrhiza uralensis
/
Sophora
/
Mezclas Complejas
/
Etanol
Límite:
Animales
Idioma:
Inglés
Revista:
Korean Journal of Veterinary Research
Año:
2014
Tipo del documento:
Artículo
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