Sedative Effect of Sophora flavescens and Matrine
Biomolecules & Therapeutics
;
: 390-395, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-129204
ABSTRACT
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the brain utilizing immunohistochemical method and enzyme-linked immunosorbent assay. The results showed that SF and matrine administration had an effect on normalization of caffeine-induced hyperactivity and promoting a shift toward non-rapid eye movement (NREM) sleep. c-Fos-immunoreactivity and 5-HT level in the ventrolateral preoptic nucleus (VLPO), a sleep promoting region, were increased in the both SF and matrine-injected groups. In conclusion, SF and its bioactive compound, matrine alleviated caffeine-induced hyperactivity and promoted NREM sleep by activating VLPO neurons and modulating serotonergic transmission. It is suggested that SF might be a useful natural alternatives for hypnotic medicine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Área Preóptica
/
Encéfalo
/
Ensayo de Inmunoadsorción Enzimática
/
Serotonina
/
Sophora
/
Electroencefalografía
/
Movimientos Oculares
/
Hipnóticos y Sedantes
/
Métodos
/
Actividad Motora
Límite:
Animales
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2017
Tipo del documento:
Artículo
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