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Declining concentrations of dehydroepiandrosterone sulfate and free testosterone with advancing age / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology ; : 631-635, 2009.
Artículo en Coreano | WPRIM | ID: wpr-129495
ABSTRACT

OBJECTIVE:

To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging.

METHODS:

One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically.

RESULTS:

The levels of DHEAS were 211.39+/-33.01 microg/dL (twenties, n=10), 127.99+/-11.79 microg/dL (thirties, n=31), 94.30+/-7.49 microg/dL (forties, n=57) and 71.79+/-5.71 microg/dL (over fifties, n=33) respectively (mean+/-SE, P<0.001). The levels of FT were 3.98+/-0.94 pg/ml (twenties, n=10), 3.37+/-0.47 pg/mL (thirties, n=31), 2.68+/-0.30 pg/mL (forties, n=57) and 1.97+/-0.28 pg/mL (fifties, n=33) respectively (mean+/-SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007).

CONCLUSION:

Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligomenorrea / Testosterona / Envejecimiento / Radioinmunoensayo / Deshidroepiandrosterona / Sulfato de Deshidroepiandrosterona / Amenorrea / Hirsutismo Límite: Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligomenorrea / Testosterona / Envejecimiento / Radioinmunoensayo / Deshidroepiandrosterona / Sulfato de Deshidroepiandrosterona / Amenorrea / Hirsutismo Límite: Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2009 Tipo del documento: Artículo