Overexpression of hTERT and c-erbB-2 are correlated in ovarian epithelial cancer / 부인종양
Korean Journal of Gynecologic Oncology
; : 142-146, 2006.
Article
en En
| WPRIM
| ID: wpr-129885
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: It is still unclear how the abnormal hTERT expression is involved in the process of ovarian carcinogenesis. A recent report demonstrated that the introduction of c-erbB-2 could efficiently induce tumorigenicity of cells with the transfection of SV40 large T antigen and hTERT. It is designed to find correlation between overexpression of hTERT and c-erbB-2 in ovarian carcinogenesis. METHODS: Using immunohistochemistry, we tested whether overexpression of hTERT and c-erbB-2 were associated in ovarian cancer. Immunohistochemical staining of hTERT and c-erbB-2 was done in 63 cases of ovarian cancer. Overexpression of hTERT and c-erbB-2 were correlated to clinicopathological variables. RESULTS: Overexpression of hTERT was found in 7 (11.1%) of cases, whereas overexpression of c-erbB2 was founded in 3 (4.8%) of cases. It was found that overexpression of hTERT and c-erbB-2 were significantly correlated (p=0.03). Neither overexpression of hTERT nor that of c-erbB-2 was associated with any of clinicopathological variables, such as stage, grade, and histology. CONCLUSION: Although the significant correlation between hTERT and c-erbB-2 was found, the low frequency of overexpression of hTERT and c-erbB-2 suggests that cooperation of hTERT and c-erbB-2 may be minor mechanism of ovarian carcinogenesis.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Neoplasias Ováricas
/
Inmunohistoquímica
/
Transfección
/
Receptor ErbB-2
/
Carcinogénesis
/
Antígenos Virales de Tumores
Idioma:
En
Revista:
Korean Journal of Gynecologic Oncology
Año:
2006
Tipo del documento:
Article