A Case of Pseudomembranous Colitis due to Clostridium difficile

ABSTRACT

Pseudomembranous colitis may result from abnormal growth of toxigenic strains of Clostridium difficile associated with antibiotic-induced alteration of the colonic microbiologic flora. C. difficile, a spore forming gram positive obligate anaerobic bacillus, is part of the normal flora and known to be the major cause of pseudomembranous colitis. We experienced a case of pseudomembranous colitis in a 14-month-old male presented with bloody mucoid diarrhea and fever who had received broad spectrum antibiotics for the treatment of pneumonia. This case was diagnosed with sigmoidoscopy and confirmed by isolation of the organism on culture with selective media TCCFA. All antibiotics were discontinued and vancomycin was administrated orally. He showed a good response.