Role of hepcidin in the pathophysiology and diagnosis of anemia
Blood Research
;
: 10-15, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-132584
ABSTRACT
This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic role of hepcidin in different types of anemia. In addition, the usefulness of hepcidin dosage is highlighted, including the problems associated with analytical methods currently used as well as the measures of its molecular isoforms. Considering the central role of hepcidin in iron arrangement, it is reasonable to ponder its therapeutic use mainly in cases of iron overload. Further clinical trials are required before implementation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sobrecarga de Hierro
/
Isoformas de Proteínas
/
Péptidos Catiónicos Antimicrobianos
/
Proteínas de Transporte de Catión
/
Eritropoyesis
/
Homeostasis
/
Anemia
/
Hierro
Tipo de estudio:
Estudio diagnóstico
Idioma:
Inglés
Revista:
Blood Research
Año:
2013
Tipo del documento:
Artículo
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