Does blastomere biopsy in preimplantation genetic diagnosis affect early serum beta-hCG levels? / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 31-36, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-133474
ABSTRACT
OBJECTIVE:
To determine whether the serum beta-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles.METHODS:
A total of 129 PGD cycles and 1,161 age-matched ICSI cycles, which resulted in pregnancy (serum beta-hCG> or =5 mIU/mL) on post-ovulation day (POD) 12 were included. We compared the mean serum beta-hCG levels on POD 12, 14, 21, and 28, doubling time of serum hCG, and created a cut-off value for predicting a singleton pregnancy in each group.RESULTS:
The mean serum beta-hCG concentration of the PGD group was significantly lower than that of the control group on POD 12, 14, and 21. The doubling time of serum beta-hCG at each time interval showed no significant difference. The cut-off-value of serum beta-hCG for predicting a single viable pregnancy was 32.5 mIU/mL on POD 12 and 113.5 mIU/mL on POD 14 for the PGD group, which was lower than that for the control group.CONCLUSION:
Blastomere biopsy may decrease the beta-hCG-producing activity of the trophoblasts, especially in early pregnancy. Setting a lower cut-off value of serum beta-hCG for predicting pregnancy outcomes in PGD may be needed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Prostaglandinas D
/
Trofoblastos
/
Biopsia
/
Blastómeros
/
Resultado del Embarazo
/
Diagnóstico Preimplantación
/
Inyecciones de Esperma Intracitoplasmáticas
/
Gonadotropina Coriónica
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Clinical and Experimental Reproductive Medicine
Año:
2011
Tipo del documento:
Artículo
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