Neural Correlates of Motor Recovery Measured by SPECT at Six Months After Basal Ganglia Stroke
Annals of Rehabilitation Medicine
; : 905-914, 2017.
Article
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| WPRIM
| ID: wpr-134084
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To investigate neural correlates associated with recovery of motor function over 6 months in patients with basal ganglia (BG) stroke using acetazolamide (ACZ) stress brain-perfusion single-photon emission computed tomography (SPECT). METHODS: Medical records of 22 patients presenting first-ever BG stroke were retrospectively reviewed. Regional cerebral blood flow (CBF) and cerebrovascular reserve (CVR) were measured for 9 regions in each cerebral hemisphere (primary motor cortex, supplementary motor area, premotor cortex, prefrontal cortex, temporal lobe, parietal lobe, occipital lobe, BG, and thalamus). The Fugl-Meyer Assessment (FMA) motor score was used to assess motor function. RESULTS: After ACZ injection, CBF of all regions of interest (ROIs) increased compared with baseline. Baseline CBF of all ROIs was not significantly correlated with changes in FMA upper or lower motor score. However, multivariate analysis revealed CVR was significantly associated with change in FMA upper score in the ipsilateral primary motor cortex (R2=0.216, p=0.017), the ipsilateral parietal lobe (R2=0.135, p=0.029), and the contralateral primary motor cortex (R2=0.210, p=0.041). CONCLUSION: CVR in the bilateral primary motor cortex and ipsilateral parietal lobe was associated with restoration of upper motor function 6 months after BG stroke. SPECT is a readily available imaging modality useful in studying brain residual function in patients with BG stroke.
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Índice:
WPRIM
Asunto principal:
Lóbulo Parietal
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Lóbulo Temporal
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Ganglios Basales
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Encéfalo
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Tomografía Computarizada de Emisión
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Tomografía Computarizada de Emisión de Fotón Único
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Circulación Cerebrovascular
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Registros Médicos
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Análisis Multivariante
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Estudios Retrospectivos
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Annals of Rehabilitation Medicine
Año:
2017
Tipo del documento:
Article