Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
Journal of Korean Medical Science
;
: 979-982, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-134503
ABSTRACT
Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Análisis Mutacional de ADN
/
Biomarcadores
/
Pruebas Genéticas
/
Prevalencia
/
Factores de Riesgo
/
Bacteriemia
/
Medición de Riesgo
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Receptor Toll-Like 2
Tipo de estudio:
Estudio de etiología
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2006
Tipo del documento:
Artículo
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