A Case of Gilbert's Syndrome with Severe Neonatal Hyperbilirubinemia
Journal of the Korean Society of Neonatology
;
: 266-269, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-134721
ABSTRACT
Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population has Gilbert's syndrome. Commonly, Gilbert's syndrome causes mild symptoms. However, a case of Gilbert's syndrome with severe neonatal hyperbilirubinemia is presented here. The patient developed jaundice three days after birth. Five days after birth, the patient's total serum bilirubin level was 34 mg/dL. The patient received intensive phototherapy and was given oral phenobarbital. Hemolytic hyperbilirubinemia was excluded on the basis of laboratory tests. Heterozygote polymorphisms of the promoter region (-3279T>G) and exon 1 (211G>A) were found in UGT1A1 gene. After discharge, the patient did not require any further treatment. This is the first case of proven Gilbert's syndrome with severe neonatal hyperbilirubinemia in Korea.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenobarbital
/
Fototerapia
/
Uridina Difosfato
/
Bilirrubina
/
Exones
/
Regiones Promotoras Genéticas
/
Glucuronosiltransferasa
/
Parto
/
Hiperbilirrubinemia Neonatal
/
Enfermedad de Gilbert
Límite:
Humanos
/
Recién Nacido
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of the Korean Society of Neonatology
Año:
2010
Tipo del documento:
Artículo
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