Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs
Journal of Periodontal & Implant Science
;
: 50-58, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-135238
ABSTRACT
PURPOSE:
This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model.METHODS:
A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4x4x5 mm (buccolingual widthxmesiodistal widthxdepth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations.RESULTS:
Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone.CONCLUSIONS:
In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteogénesis
/
Enfermedades Periodontales
/
Polímeros
/
Poríferos
/
Polvos
/
Regeneración
/
Diente Premolar
/
Sustitutos de Huesos
/
Trasplantes
/
Ingeniería de Tejidos
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Periodontal & Implant Science
Año:
2012
Tipo del documento:
Artículo
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