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Detailed Characterization of Chromosomal Breakpoints in an ALL, L3 using Cross Species Color Banding / 대한임상병리학회지
Korean Journal of Clinical Pathology ; : 516-519, 2000.
Artículo en Coreano | WPRIM | ID: wpr-135676
ABSTRACT
Karyotype analysis by G-anding is the standard method for identifying numerical and structural chromosomal aberrations in cytogenetic laboratories. However, the origins of marker chromosomes, subtle translocations, or complex chromosomal rearrangements are often difficult to identify with certainty. Cross-pecies color banding is a new FISH-ased screening technique that enables the generation of a specific color banding pattern for each human chromosome based on the genomic homologies between man and various species of apes. We report application of Cross-pecies color banding (RxFISH) to characterize the chromosomal rearrangements of one leukemia sample the G-and karyotype of which were incomplete. The combination of G-anding and RxFISH in this case study yielded additional information beyond that obtained by either technique used alone in determining the precise breakpoints in complex chromosomal rearrangements.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Hominidae / Leucemia / Tamizaje Masivo / Aberraciones Cromosómicas / Cromosomas Humanos / Citogenética / Cariotipo Tipo de estudio: Estudio de tamizaje Límite: Humanos Idioma: Coreano Revista: Korean Journal of Clinical Pathology Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Hominidae / Leucemia / Tamizaje Masivo / Aberraciones Cromosómicas / Cromosomas Humanos / Citogenética / Cariotipo Tipo de estudio: Estudio de tamizaje Límite: Humanos Idioma: Coreano Revista: Korean Journal of Clinical Pathology Año: 2000 Tipo del documento: Artículo