Polycan-calcium gluconate complex improves gingival health / 대한구강보건학회지

ABSTRACT

OBJECTIVES: The aim of this study was to examine the effect of a Polycan-calcium gluconate complex on gingival health. METHODS: Forty-one subjects with mild periodontitis (> or =40 years) were divided into two groups the placebo and test product (Polycan-calcium gluconate complex twice a day for 4 weeks) groups. Oral examination was performed and gingival crevicular fluid (GCF) was collected from each subject at baseline and after 4 weeks. Interleukin (IL)-1beta level in the GCF was determined using enzyme-linked immunosorbent assay. RESULTS: Pocket depth and plaque index were significantly decreased in the test group at 4 weeks. The level of IL-1beta and plaque index of the treatment group was significantly lower than of the placebo group. CONCLUSIONS: Based on the above results, Polycan-calcium gluconate complex may inhibit plaque accumulation in the mouth and may have a negative correlation with the level of inflammatory biomarkers. Consequently, gingival health was significantly improved by polycan-calcium gluconate complex.