Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell
Korean Journal of Audiology
;
: 108-113, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-136516
ABSTRACT
The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Permeabilidad
/
Acetilcolina
/
Calcio
/
Receptores Nicotínicos
/
Cóclea
/
Canales de Potasio Calcio-Activados
/
Cabello
Idioma:
Inglés
Revista:
Korean Journal of Audiology
Año:
2012
Tipo del documento:
Artículo
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