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LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils
Experimental & Molecular Medicine ; : 325-333, 2009.
Artículo en Inglés | WPRIM | ID: wpr-136588
ABSTRACT
Serum amyloid A (SAA) has been regarded as an important mediator of inflammatory responses. The effect of several formyl peptide receptor-like 1 (FPRL1) ligands on the production of IL-8 by SAA was investigated in human neutrophils. Among the ligands tested, LL-37 was found to specifically inhibit SAA-induced IL-8 production in transcriptional and post-transcriptional levels. Since SAA stimulated IL-8 production via ERK and p38 MAPK in human neutrophils, we tested the effect of LL-37 on SAA induction for these two MAPKs. LL-37 caused a dramatic inhibition of ERK and p38 MAPK activity, which is induced by SAA. LL-37 was also found to inhibit SAA-stimulated neutrophil chemotactic migration. Further, the LL-37-induced inhibitory effect was mediated by FPRL1. Our findings indicate that LL-37 is expected to be useful in the inhibition of SAA signaling and for the development of drugs against SAA-related inflammatory diseases.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Transcripción Genética / Proteína Amiloide A Sérica / Transducción de Señal / Movimiento Celular / Quimiotaxis de Leucocito / Interleucina-8 / Proteínas Proto-Oncogénicas / Quinasas Quinasa Quinasa PAM / Péptidos Catiónicos Antimicrobianos / Línea Celular Tumoral Límite: Animales / Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Transcripción Genética / Proteína Amiloide A Sérica / Transducción de Señal / Movimiento Celular / Quimiotaxis de Leucocito / Interleucina-8 / Proteínas Proto-Oncogénicas / Quinasas Quinasa Quinasa PAM / Péptidos Catiónicos Antimicrobianos / Línea Celular Tumoral Límite: Animales / Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2009 Tipo del documento: Artículo