Clinical Study of Prevalence of Antibiotic Resistance of Escherichia coli in Urinary Tract Infection in Children: A 9-year Retrospective, Single Center Experience
Childhood Kidney Diseases
;
: 121-127, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-136726
ABSTRACT
PURPOSE:
The aim of this study was to determine the prevalence of antibiotic susceptibility and resistance of Escherichia coli in urinary tract infections (UTIs) in children.METHODS:
We retrospectively reviewed the clinical records of 212 inpatients aged 18 years or younger with UTIs treated at the Pediatric Department of Dongguk University Gyeongju Hospital between January 2008 and December 2016. For comparison, patients were divided into three groups according to age as follows group 1, ≤1 month; group 2, >1 month to ≤12 months; and group 3, ≥13 months. The antibiotic resistance rates from January 2008 to December 2012 (study period 1) and from January 2013 to December 2016 (study period 2) were analyzed statistically by group.RESULTS:
As the patient age increased, the antibiotic resistance rate to ampicillin (P=0.013), levofloxacin (P=0.050), piperacillin/tazobactam (TZP) (P<0.001), and trimethoprim/sulfamethoxazole (P=0.002) increased. The frequency of extended spectrum beta-lactamase producing E. coli showed a significant difference from 5 cases (4.6%) in study period 1 and 16 cases (15.8%) in study period 2 (P=0.007). The antibiotic resistance rate of E. coli was compared between the two time periods and we found that the antibiotic resistance rate to cefotaxime was significantly increased from 5.4% to 16.8% (P=0.008) and that to TZP was significantly decreased from 40.5% to 7.9% (P<0.001).CONCLUSION:
Over the past 9 years, the resistance rate to cefotaxime has increased but the resistance rate to TZP has decreased. Thus, it is important to continue to investigate the antibiotic resistance rates of bacteria in the community.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bacterias
/
Sistema Urinario
/
Infecciones Urinarias
/
Beta-Lactamasas
/
Farmacorresistencia Microbiana
/
Cefotaxima
/
Prevalencia
/
Estudios Retrospectivos
/
Escherichia
/
Escherichia coli
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Childhood Kidney Diseases
Año:
2017
Tipo del documento:
Artículo
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