Maternal Plasma Hepatocyte Growth Factor Concentrations in Women Who Subsequently Developed Preeclampsia
Journal of Genetic Medicine
;
: 78-83, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-137170
ABSTRACT
PURPOSE:
The aim of this nested case-control study was to investigate the association between hepatocyte growth factor (HGF) concentrations in maternal plasma and the risk of developing preeclampsia. MATERIALS ANDMETHODS:
Plasma HGF concentration were measured in 52 women who subsequently developed preeclampsia and 104 normal pregnant women at the time of genetic amniocentesis (15-20 weeks) by enzyme-linked immunosorbent assay.RESULTS:
Maternal plasma HGF concentrations were significantly higher in women with subsequent preeclampsia (median 737.8 ng/mL vs. 670.4 ng/mL, P=0.003) than in normal controls. However, HGF concentrations were not significantly different between subgroups by preeclamptic complications. After adjusting for potential confounding factors, women with HGF concentrations > or =702.5 ng/mL had a 3.2-fold increased risk (95% CI 2.7-5.4, P<0.001) of subsequent development of preeclampsia compared with women with HGF concentrations <702.5 ng/mL.CONCLUSION:
Elevated maternal plasma HGF concentrations in the early second-trimester are associated with an increased risk of developing preeclampsia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Preeclampsia
/
Estudios de Casos y Controles
/
Factores de Riesgo
/
Factor de Crecimiento de Hepatocito
/
Hepatocitos
/
Mujeres Embarazadas
/
Amniocentesis
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Genetic Medicine
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS