The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children
Allergy, Asthma & Immunology Research
;
: 251-255, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-13722
ABSTRACT
PURPOSE:
Asthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this study, the associations of 25-hydroxy vitamin D3 levels with asthma and with the severity of asthma were evaluated.METHODS:
This cross-sectional study was conducted on 50 asthmatic children and 50 healthy controls aged 6-18 years. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups. The relationship between serum vitamin D levels and pulmonary function test outcomes and eosinophil counts were examined in asthmatic patients.RESULTS:
Univariate analysis of the relationship between asthma and vitamin D showed that decreased vitamin D levels were associated with significantly increased odds of asthmatic state (P=0.002). In a multivariate analysis after adjustment for age, body mass index, and sex, the relationship between vitamin D and asthma increased. In asthmatic patients, 25-hydroxy vitamin D levels had direct and significant correlations with both predicted FEV1 (R2=0.318; P=0.024) and FEV1/FVC (R2=0.315; P=0.026). There were no associations between vitamin D level and eosinophil counts, duration of disease, and the number of hospitalization or unscheduled visits in the previous year (P>0.05).CONCLUSIONS:
These results showed that serum 25-hydroxy vitamin D levels were inversely associated with asthma, and there was a direct and significant relationship between vitamin D levels and pulmonary function test outcomes in asthmatic children. An interventional study in asthmatic patients with low serum vitamin D concentration may establish a causal relationship between asthma and vitamin D.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pruebas de Función Respiratoria
/
Asma
/
Vitamina D
/
Deficiencia de Vitamina D
/
Vitaminas
/
Índice de Masa Corporal
/
Estudios Transversales
/
Análisis Multivariante
/
Colecalciferol
/
Eosinófilos
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
Allergy, Asthma & Immunology Research
Año:
2011
Tipo del documento:
Artículo
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