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A missense polymorphism (rs11895564, Ala380Thr) of integrin alpha 6 is associated with the development and progression of papillary thyroid carcinoma in Korean population / 대한외과학회지
Article en En | WPRIM | ID: wpr-139168
Biblioteca responsable: WPRO
ABSTRACT
PURPOSE: Integrins play crucial roles in the pathogenesis of papillary thyroid carcinoma (PTC). The aim of this study was to investigate whether two single nucleotide polymorphisms (SNPs) (rs2141698, -1687A/G; rs11895564, Ala380Thr) of the integrin alpha 6 (ITGA6) gene are associated with the development and clinicopathologic characteristics of PTC such as the size ( or =1 cm), number (unifocality and multifocality), location (one lobe and both lobes), extrathyroid invasion, and cervical lymph node metastasis. METHODS: We enrolled 104 PTC patients and 318 control subjects. Genotypes of each SNP were determined by direct sequencing. SNPStats, SNPAnalyzer, and Helixtree programs were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs), and P-values. Multiple logistic regression models were performed to analyze genetic data. RESULTS: A missense SNP rs11895564 was associated with the development of PTC. The A allele frequency of rs11895564 was higher in PTC patients than in controls (13.5% vs. 7.1%; P = 0.005; OR, 2.04; 95% CI, 1.24 to 3.37). In the clinicopathologic characteristics, the A allele frequency of rs11895564 showed difference in the size (19.6% in or =1 cm; P = 0.010; OR, 0.30; 95% CI, 0.12 to 0.75) and number (8.5% in unifocality vs. 20.8% in multifocality; P = 0.015; OR, 2.85; 95% CI, 1.23 to 6.59) of PTC. CONCLUSION: These results suggest that the A allele of rs11895564 (Ala380Thr) in ITGA6 may be a risk factor of PTC, and also contribute to the progression of PTC in the Korean population.
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Texto completo: 1 Índice: WPRIM Asunto principal: Glándula Tiroides / Factor IX / Neoplasias de la Tiroides / Carcinoma / Integrinas / Modelos Logísticos / Oportunidad Relativa / Factores de Riesgo / Polimorfismo de Nucleótido Simple / Alelos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Journal of the Korean Surgical Society Año: 2011 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Glándula Tiroides / Factor IX / Neoplasias de la Tiroides / Carcinoma / Integrinas / Modelos Logísticos / Oportunidad Relativa / Factores de Riesgo / Polimorfismo de Nucleótido Simple / Alelos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Journal of the Korean Surgical Society Año: 2011 Tipo del documento: Article