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Measurement of Precuneal and Hippocampal Volumes Using Magnetic Resonance Volumetry in Alzheimer's Disease
Journal of Clinical Neurology ; : 196-203, 2010.
Artículo en Inglés | WPRIM | ID: wpr-139694
ABSTRACT
BACKGROUND AND

PURPOSE:

Alzheimer's disease (AD) is associated with structural alterations in the medial temporal lobe (MTL) and functional alterations in the posterior cortical region, especially in the early stages. However, it is unclear what mechanisms underlie these regional discrepancies or whether the posterior cortical hypometabolism reflects disconnection from the MTL lesion or is the result of local pathology. The precuneus, an area of the posteromedial cortex that is involved in the early stages of AD, has recently received a great deal of attention in functional neuroimaging studies. To assess the relationship between the precuneus and hippocampus in AD, we investigated the volumes of these two areas using a magnetic resonance volumetric method.

METHODS:

Twenty-three subjects with AD and 14 healthy age-matched controls underwent T1-weighted three-dimensional volumetric brain magnetic resonance imaging. Volumetric measurements were performed in the precuneus and hippocampus.

RESULTS:

Compared to controls, AD patients exhibited a significant reduction in total precuneal volume, which was more prominent on the right side, and significant bilateral reductions in hippocampal volume. No correlation was found between the total volumes of the precuneus and hippocampus in the AD group.

CONCLUSIONS:

These results suggest that volumetric measurements of both the precuneus and hippocampus are useful radiological indices for the diagnosis of AD. Furthermore, the lack of correlation is attributable to local pathology rather than being a secondary consequence of MTL pathology.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lóbulo Temporal / Encéfalo / Imagen por Resonancia Magnética / Espectroscopía de Resonancia Magnética / Enfermedad de Alzheimer / Neuroimagen Funcional / Imanes / Hipocampo / Magnetismo Límite: Humanos Idioma: Inglés Revista: Journal of Clinical Neurology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lóbulo Temporal / Encéfalo / Imagen por Resonancia Magnética / Espectroscopía de Resonancia Magnética / Enfermedad de Alzheimer / Neuroimagen Funcional / Imanes / Hipocampo / Magnetismo Límite: Humanos Idioma: Inglés Revista: Journal of Clinical Neurology Año: 2010 Tipo del documento: Artículo