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A Case Report of Mantle Cell Lymphoma in Leukemic Phase / 대한임상병리학회지
Korean Journal of Clinical Pathology ; : 539-546, 1997.
Artículo en Coreano | WPRIM | ID: wpr-13998
ABSTRACT
Recently, we experienced a patient with a B cell leukemia which could not be classified as chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PL) or follicular lymphoma in leukemic phase. He is a 58-year-old male and suffered from progressive lymphadenopathy at both inguinal and cervical areas. His blood film showed lymphocytosis (79%), and the cells were heterogeneous in size and shape. Twenty-five percent of the lymphocytes had nuclear irregularities or cleavages unlike the lymphocytes of CLL In which the cells often shows monomorphic features, small size with scanty cytoplasm and round nucleus. The bone marrow trephine biopsy specimen showed a diffuse pattern of infiltration of atypical Iymphoid cells. The lymph node histology showed atypical lymphoid colls proliferated as wide mantles around non-neoplastic appearing germinal centers. The immunophenotype of circulating lymphocytes in peripheral blood showed strong reactivity with CD5, CDl9 and CD20 without expression of CD2, CD3, CD7, CD10, CD22 and CD23. Although this case resembled CLL, the laboratory features showed major differences, notably in the Peripheral blood morphology, histology Patterns and the membrane Phenotype. By combining these data, we diagnosed this case as a leukemic phase of mantle cell lymphoma.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Biopsia / Médula Ósea / Linfocitos / Leucemia de Células B / Leucemia Linfocítica Crónica de Células B / Leucemia Prolinfocítica / Linfoma Folicular / Centro Germinal / Linfoma de Células del Manto Límite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Clinical Pathology Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Biopsia / Médula Ósea / Linfocitos / Leucemia de Células B / Leucemia Linfocítica Crónica de Células B / Leucemia Prolinfocítica / Linfoma Folicular / Centro Germinal / Linfoma de Células del Manto Límite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Clinical Pathology Año: 1997 Tipo del documento: Artículo