A Case Report of Mantle Cell Lymphoma in Leukemic Phase / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 539-546, 1997.
Artículo
en Coreano
| WPRIM
| ID: wpr-13998
ABSTRACT
Recently, we experienced a patient with a B cell leukemia which could not be classified as chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PL) or follicular lymphoma in leukemic phase. He is a 58-year-old male and suffered from progressive lymphadenopathy at both inguinal and cervical areas. His blood film showed lymphocytosis (79%), and the cells were heterogeneous in size and shape. Twenty-five percent of the lymphocytes had nuclear irregularities or cleavages unlike the lymphocytes of CLL In which the cells often shows monomorphic features, small size with scanty cytoplasm and round nucleus. The bone marrow trephine biopsy specimen showed a diffuse pattern of infiltration of atypical Iymphoid cells. The lymph node histology showed atypical lymphoid colls proliferated as wide mantles around non-neoplastic appearing germinal centers. The immunophenotype of circulating lymphocytes in peripheral blood showed strong reactivity with CD5, CDl9 and CD20 without expression of CD2, CD3, CD7, CD10, CD22 and CD23. Although this case resembled CLL, the laboratory features showed major differences, notably in the Peripheral blood morphology, histology Patterns and the membrane Phenotype. By combining these data, we diagnosed this case as a leukemic phase of mantle cell lymphoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Biopsia
/
Médula Ósea
/
Linfocitos
/
Leucemia de Células B
/
Leucemia Linfocítica Crónica de Células B
/
Leucemia Prolinfocítica
/
Linfoma Folicular
/
Centro Germinal
/
Linfoma de Células del Manto
Límite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Clinical Pathology
Año:
1997
Tipo del documento:
Artículo
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