Immune Response to Helicobacter pylori Infection

ABSTRACT

Helicobacter pylori infection leads to immune responses associated with almost all mechanism of innate and acquired immunity. However, clinical manifestation of H. pylori infection varies from asymptomatic gastritis to gastric cancer. The balance between harmful injury in gastric mucosa and protective role of immune mechanisms may be influenced by the variability of bacterial virulence factors, host susceptibility, and environmental factors. In this review, we describe the inflammatory response of H. pylori infection and protective mechanism against H. pylori infection. Better understanding of the mechanism of the immune response to H. pylori infection can be helpful in the development of new therapeutic strategies and prophylactic vaccine.