Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis
Journal of Korean Medical Science
; : 1199-1204, 2014.
Article
en En
| WPRIM
| ID: wpr-140358
Biblioteca responsable:
WPRO
ABSTRACT
Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-alpha and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8+/-14.4 vs. 22.2+/-6.1 ng/mL; P or =2.6) were significantly higher than those in remission (DAS28<2.6) (36.45+/-14.36 vs. 24.63+/-8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-alpha and it may be a novel biomarker for assessing inflammatory activity in patients with RA.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Artritis Reumatoide
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Índice de Severidad de la Enfermedad
/
Sedimentación Sanguínea
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Proteína C-Reactiva
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Ensayo de Inmunoadsorción Enzimática
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Glicoproteínas
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Biomarcadores
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Curva ROC
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Factor de Necrosis Tumoral alfa
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Área Bajo la Curva
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2014
Tipo del documento:
Article