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Aminophylline Partially Prevents the Decrease of Body Temperature during Laparoscopic Abdominal Surgery
Journal of Korean Medical Science ; : 1161-1165, 2014.
Artículo en Inglés | WPRIM | ID: wpr-141019
ABSTRACT
Aminophylline can elicit thermogenesis in rats or increase metabolic rate during cold stress in lambs. We tested the hypothesis that aminophylline would reduce the change in core body temperature during laparoscopic abdominal surgery requiring pneumoperitoneum. Fifty patients were randomly divided into an aminophylline group (n=25) and a saline control group (n=25). Esophageal temperature, index finger temperature, and hemodynamic variables, such as mean blood pressure and heart rate, were measured every 15 min during sevoflurane anesthesia. In the aminophylline group, esophageal temperatures at T45 (36.1+/-0.38 vs. 35.7+/-0.29, P=0.024), T60 (36.0+/-0.39 vs. 35.6+/-0.28, P=0.053), T75 (35.9+/-0.34 vs. 35.5+/-0.28, P=0.025), T90 (35.8+/-0.35 vs. 35.3+/-0.33, P=0.011), and T105 (35.8+/-0.36 vs. 35.1+/-0.53, P=0.017) and index finger temperatures at T15 (35.8+/-0.46 vs. 34.9+/-0.33, P<0.001), T30 (35.7+/-0.36 vs. 35.0+/-0.58, P=0.029), T45 (35.8+/-0.34 vs. 35.2+/-0.42, P=0.020), T60 (35.7+/-0.33 vs. 34.9+/-0.47, P=0.010), T75 (35.6+/-0.36 vs. 34.8+/-0.67, P=0.028), T90 (35.4+/-0.55 vs. 34.4+/-0.89, P=0.042), and T105 (34.9+/-0.53 vs. 33.9+/-0.85, P=0.024) were significantly higher than in the saline control group. Aminophylline is effective in maintaining the core temperature through a thermogenic effect, despite reduced peripheral thermoregulatory vasoconstriction.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumoperitoneo Artificial / Temperatura Corporal / Método Simple Ciego / Resultado del Tratamiento / Laparoscopía / Abdomen / Aminofilina / Hipotermia Tipo de estudio: Ensayo Clínico Controlado Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumoperitoneo Artificial / Temperatura Corporal / Método Simple Ciego / Resultado del Tratamiento / Laparoscopía / Abdomen / Aminofilina / Hipotermia Tipo de estudio: Ensayo Clínico Controlado Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2014 Tipo del documento: Artículo