Cytogenetic and clinical analysis of midtrimester amniocentesis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1420-1430, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-14109
ABSTRACT
OBJECTIVE:
To analyze the clinical features and cytogenetic results of midtrimester amniocentesis.METHODS:
We reviewed retrospectively medical records of 1,622 women who received amniocentesis from 1998 to 2003. The maternal age and gestational age at amniocentesis, indications, cytogenetic results and complications of amniocentesis were analyzed.RESULTS:
A total of 1,653 cases of amniocentesis were performed in 1,590 singleton pregnancies and 32 twin pregnancies. The mean age at amniocentesis of singleton pregnancies was 33.5 +/- 4.3 years, and the most common age group was from 35 to 39 (38.6%) and those of twin pregnancies were 33.1 +/- 3.6 years and from 30 to 34 (50.0%), respectively. Majority of the cases (78.9%) were performed between 16th and 19th weeks of gestation. Advanced maternal age was the most common indication of amniocentesis (46.2%), followed by abnormal serum screening test (32.9%) and abnormal ultrasonographic findings (10.0%). Abnormal fetal karyotype results were identified in 34 cases (2.1%). 24 cases were numerical aberration and the other 10 cases were structural aberration. Trisomy 21 was the most common abnormal karyotype (23.5%). There was no abnormal karyotype results from 63 amniocentesis performed in twin pregnancies. Positive predictive value of abnormal ultrasonographic finding, advanced maternal age and abnormal serum screening test were 3.0%, 2.5%, 1.5% respectively. The procedure-related fetal death occurred in 7/1,353 (0.51%).CONCLUSION:
Among the several indications of midtrimester amniocentesis, advanced maternal age was the most common indication, whereas abnormal ultrasonographic finding had the most powerful predictive value for abnormal fetal karyotype.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Segundo Trimestre del Embarazo
/
Diagnóstico Prenatal
/
Tamizaje Masivo
/
Registros Médicos
/
Estudios Retrospectivos
/
Edad Gestacional
/
Edad Materna
/
Síndrome de Down
/
Citogenética
/
Muerte Fetal
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2005
Tipo del documento:
Artículo
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