Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes
Endocrinology and Metabolism
;
: 309-319, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-141181
ABSTRACT
BACKGROUND:
It is not clear whether microangiopathies are associated with subclinical atherosclerosis in type 2 diabetes mellitus (T2DM). We investigated the relation of cardiac autonomic neuropathy (CAN) and other microangiopathies with carotid atherosclerosis in T2DM.METHODS:
A total of 131 patients with T2DM were stratified by mean carotid intima-media thickness (CIMT) > or = or or =2. Diabetic microangiopathies were assessed.RESULTS:
Patients with CAN comprised 77% of the group with mean CIMT > or =1.0 mm, while they were 29% of the group with CIMT or =1.0 mm, while they were 28% of the group without CIMT thickening (P=0.003). Patients with CAN comprised 51% of the group with > or =2 carotid plaques, while they were 23% of the group with < or =1 carotid plaque (P=0.014). In multivariable adjusted logistic regression analysis, the patients who presented with CAN showed an odds ratio [OR] of 8.6 (95% confidence interval [CI], 1.6 to 44.8) for CIMT thickening and an OR of 2.9 (95% CI, 1.1 to 7.5) for carotid plaques. Furthermore, patients with DR were 3.8 times (95% CI, 1.4 to 10.2) more likely to have CIMT thickening.CONCLUSION:
These results suggest that CAN is associated with carotid atherosclerosis, represented as CIMT and plaques, independent of the traditional cardiovascular risk factors in T2DM. CAN or DR may be a determinant of subclinical atherosclerosis in T2DM.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Reflejo
/
Enfermedades de las Arterias Carótidas
/
Modelos Logísticos
/
Oportunidad Relativa
/
Factores de Riesgo
/
Diabetes Mellitus Tipo 2
/
Angiopatías Diabéticas
/
Neuropatías Diabéticas
/
Retinopatía Diabética
/
Aterosclerosis
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Endocrinology and Metabolism
Año:
2013
Tipo del documento:
Artículo
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