No evidence of association between interleukin-13 gene polymorphism in aspirin intolerant chronic urticaria
Allergy, Asthma & Immunology Research
; : 36-40, 2009.
Article
en En
| WPRIM
| ID: wpr-141238
Biblioteca responsable:
WPRO
ABSTRACT
Aspirin-intolerant chronic urticaria (AICU) is a common condition among the chronic urticaria population, but the genetic mechanism is not yet understood. In this study, the genotypes and haplotypes of three interleukin (IL)-13 polymorphisms, -1510 A>C, -1055C>T, and Arg110Gln (110G>A), as well as their respective clinical phenotypes were examined to determine whether genetic variants of IL-13 play a role in AICU. Single-nucleotide polymorphism (SNP) genotyping was used to compare IL-13 genotype and allele frequencies among 135 patients with AICU, 146 with aspirin-tolerant chronic urticaria (ATCU), and 430 normal controls (NC). Relationships among the AICU phenotype, atopy, and total IgE level were also investigated. The results failed to show a significant difference in the allele or genotype frequencies between the AICU group and either the ATCU or NC group (P>0.05, respectively). Haplotype analysis confirmed that there was no significant difference among the three study groups (P>0.05), nor was there a significant difference in atopy or total IgE level according to the three genetic polymorphisms (P>0.05, respectively). Our data lead to the conclusion that there is no evidence supporting genetic polymorphisms in IL-13 as a genetic risk factor for the development of AICU.
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Índice:
WPRIM
Asunto principal:
Fenotipo
/
Polimorfismo Genético
/
Urticaria
/
Haplotipos
/
Inmunoglobulina E
/
Aspirina
/
Factores de Riesgo
/
Interleucinas
/
Interleucina-13
/
Alelos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Allergy, Asthma & Immunology Research
Año:
2009
Tipo del documento:
Article