Dermatophagoides pteronissinus Specific IgG Subclasses According to Severity of Exercise Induced Asthma in Allergic Children

ABSTRACT

PURPOSE: There are several controversial considerations about the roles of allergen specific IgG and IgG subclasses on allergic responses. House dust mite specific IgG4 developed delayed asthmatic responses. But close relation was reported between presence of high IgG1 antibodies and development of late asthmatic responses. The objectives of this study were to evaluate relation between early asthmatic response after exercise loading test and Dermatophagoides pteronissinus (Dp) specific IgG and IgG subclasses in Dp sensitized allergic children. METHODS: Dp sensitized sixty two children with bronchial asthma or allergic rhinitis were studied. Total eosinophil count, Dp specific IgE, IgG, and IgG subclasses were estimated and changes of peak expiratory flow rate (PEFR) were obseved after exercise loading test (free running test for 6 minutes). RESULTS: 1) Total eosinophil count, IgE, Dp specific IgE were not different between exercise induced asthma group (EIA group) and non exercise induced athma group (Non-EIA group). 2) Dp specific IgG, IgG1, IgG2, IgG3, IgG4 were not different between two groups. 3) Incidence of EIA was 51.6%. EIA children with decreasing rate of PEFR below 25% was 46.9% and group with decreasing rate of PEFR between 25% and 50% was 53.1%. 4) Dp specific IgG1, IgG2, IgG4 antibody levels were significantly higher in group with 25-50% decreasing rate of PEFR than below 25% group. CONCLUSIONS: High Dp specific IgG1, IgG2, IgG4 antibody levels were shown in the patients with severe early asthmatic response after exercise loading test.