Impact of Oral Levonorgestrel for 1 Year on Mammographic Density in Menopausal Hormone Therapy / 대한폐경학회지
The Journal of Korean Society of Menopause
; : 27-33, 2011.
Article
en Ko
| WPRIM
| ID: wpr-141951
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES: We evaluated changes in mammographic density (MMGD) after hormone therapy (HT) using levonorgestrel (LNG) in Korean postmenopausal women. METHODS: In this retrospective study, 58 healthy postmenopausal women with no history of prior HT were included. Twenty-three women were given a cyclic regimen of estradiol valerate (E) 2 mg/day + LNG 0.075 mg/day and 25 untreated women served as a negative control and 10 women treated with continuous combined regimen of conjugated equine estrogen (CEE) 0.625 mg/day + medroxyprogesterone acetate (MPA) 2.5 mg/day as a positive control. Mammography was obtained at baseline and 1 year later, and MMGD was assessed. In addition, the change in the proportion of the dense area after HT was assessed using the J-image program. Data were analyzed with analysis of variance and chi-square or Fisher's exact test. RESULTS: There were no significant differences in baseline characteristics among three groups. After 1 year of HT, increase of BI-RADS grade in CEE + MPA group (7/9, 77.8%) was higher than in E + LNG group (2/16, 12.5%; P = 0.001). But there was no difference between untreated group (1/19, 5.3%) and E + LNG group (2/16, 12.5%; P = 0.446). In subgroup analysis of women with BI-RADS grade 3 at baseline, no significant difference. Changes in the proportion of dense areas assessed by the J-image program showed similar results. Regression analysis revealed that there was no correlation between baseline dense area and changes after HT in E + LNG group. CONCLUSION: HT using LNG did not influence MMGD in Korean postmenopausal women. Further study on breast cancer risk may be needed.
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Índice:
WPRIM
Asunto principal:
Neoplasias de la Mama
/
Mamografía
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Estudios Retrospectivos
/
Levonorgestrel
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Acetato de Medroxiprogesterona
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Glándulas Mamarias Humanas
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Estradiol
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Estrógenos
Tipo de estudio:
Observational_studies
Límite:
Female
/
Humans
Idioma:
Ko
Revista:
The Journal of Korean Society of Menopause
Año:
2011
Tipo del documento:
Article