Effects of excessive dietary methionine on oxidative stress and dyslipidemia in chronic ethanol-treated rats
Nutrition Research and Practice
;
: 144-149, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-143307
ABSTRACT
BACKGROUND/OBJECTIVE:
The aim of this study was to examine the effect of high dietary methionine (Met) consumption on plasma and hepatic oxidative stress and dyslipidemia in chronic ethanol fed rats. MATERIALS/METHODS:
Male Wistar rats were fed control or ethanol-containing liquid diets supplemented without (E group) or with DL-Met at 0.6% (EM1 group) or 0.8% (EM2 group) for five weeks. Plasma aminothiols, lipids, malondialdehyde (MDA), alanine aminotransferase (ALT), and aspartate aminotransferase were measured. Hepatic folate, S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH) were measured.RESULTS:
DL-Met supplementation was found to increase plasma levels of homocysteine (Hcy), triglyceride (TG), total cholesterol (TC), and MDA compared to rats fed ethanol alone and decrease plasma ALT. However, DL-Met supplementation did not significantly change plasma levels of HDL-cholesterol, cysteine, cysteinylglycine, and glutathione. In addition, DL-Met supplementation increased hepatic levels of folate, SAM, SAH, and SAMSAH ratio. Our data showed that DL-Met supplementation can increase plasma oxidative stress and atherogenic effects by elevating plasma Hcy, TG, and TC in ethanol-fed rats.CONCLUSION:
The present results demonstrate that Met supplementation increases plasma oxidative stress and atherogenic effects by inducing dyslipidemia and hyperhomocysteinemia in ethanol-fed rats.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Aspartato Aminotransferasas
/
S-Adenosilhomocisteína
/
S-Adenosilmetionina
/
Triglicéridos
/
Colesterol
/
Ratas Wistar
/
Estrés Oxidativo
/
Hiperhomocisteinemia
/
Cisteína
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Nutrition Research and Practice
Año:
2015
Tipo del documento:
Artículo
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