Characteristics and Outcomes of Second Malignant Neoplasms after Childhood Cancer Treatment: Multi-Center Retrospective Survey
Journal of Korean Medical Science
;
: 1254-1261, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-143624
ABSTRACT
This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors of childhood cancer from multiple institutions in Korea. A total of 102 patients from 11 institutions who developed SMN after childhood cancer treatment between 1998 and 2011 were retrospectively enrolled. The most common primary malignant neoplasms (PMNs) were central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia (n = 16), non-Hodgkin lymphoma (n = 13), and osteosarcoma (n = 12). The most common SMNs were therapy-related myeloid neoplasms (t-MNs; acute myeloid leukemia [AML], 29 cases; myelodysplastic syndrome [MDS], 12 cases), followed by thyroid carcinomas (n = 15) and CNS tumors (n = 10). The median latency period was 4.9 years (range, 0.5-18.5 years). Among 45 patients with solid tumors defined as an SMN, 15 (33%) developed the lesion in a field previously subjected to radiation. The 5-year overall survival (OS) rate of patients with an SMN was 45% with a median follow-up time of 8.6 years. Patients with AML, MDS, and CNS tumors exhibited the poorest outcomes with 5-year OS rates of 18%, 33%, and 32%, respectively, whereas those with second osteosarcoma showed comparable outcomes (64%) to patients with primary counterpart and those with second thyroid carcinoma had a 100% OS rate. Further therapeutic efforts are recommended to improve the survival outcomes in patients with SMNs, especially in cases with t-MNs and CNS tumors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trasplante Autólogo
/
Síndromes Mielodisplásicos
/
Leucemia Mieloide Aguda
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Osteosarcoma
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Neoplasias Primarias Secundarias
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Neoplasias del Sistema Nervioso Central
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Supervivencia sin Enfermedad
/
Trasplante de Células Madre
Tipo de estudio:
Estudio observacional
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Humanos
/
Lactante
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2016
Tipo del documento:
Artículo
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